Research
Extension
Courses
Consumers
--------------------------
Virtual
Tours Student
& Job Opportunities News
Articles Standards
--------------------------
Market
Information Events
Issues
Animal Welfare Strategic
Plans --------------------------
Links
Award-winners
Site Map
The Macrocidins: Novel Cyclic Tetramic Acids with Herbicidal Activity Produced by Phoma macrostoma
P. R. Graupner1, A. Carr1, E. Clancy1, J. Gilbert1, K. L. Bailey2, J. Derby2 and B. C. Gerwick1
Abstract
Field isolates of Phoma macrostoma were obtained from diseased
Canada thistle growing in several geographically diverse regions. Bleaching
and chlorotic symptoms were present on the infected plants.
The isolates grown in liquid culture were found to produce phytotoxic
metabolites which also caused bleaching when applied foliarly to several
broadleaf species. Bioassay-directed isolation led to the discovery of
macrocidins A and B, the first representatives of a new family of cyclic
tetramic acids.
This new chemotype may offer significant potential as a template for herbicide
design.
Source
Journal of Natural Products (2003) 66: 1558-1561
Author Locations and Affiliations
(1) Natural Products Discovery, Dow AgroSciences, 9330 Zionsville Road, Indianapolis,
Indiana 46268
(2) Agriculture & Agri-Food Canada, 107 Science Place,
Saskatoon, Saskatchewan, Canada, S7N 0X2
Corresponding Author: Paul R. Graupner prgraupner@dow.com
en français